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  • Combo of Gout Genetics and Poor Lifestyle Can Up CVD Risk

    Combo of Gout Genetics and Poor Lifestyle Can Up CVD Risk

    TOPLINE:

    Genetic predisposition to gout, unfavorable lifestyle habits, and poor metabolic health are associated with an increased risk for cardiovascular disease (CVD); however, adherence to a healthy lifestyle can reduce this risk by up to 62%, even in individuals with high genetic risk.

    METHODOLOGY:

    • Researchers investigated the association between genetic predisposition to gout, combined with lifestyle habits, and the risk for CVD in two diverse prospective cohorts from different ancestral backgrounds.
    • They analyzed the data of 224,689 participants of European descent from the UK Biobank (mean age, 57.0 years; 56.1% women) and 50,364 participants of East Asian descent from the Korean Genome and Epidemiology Study (KoGES; mean age, 53.7 years; 66.0% women).
    • The genetic predisposition to gout was evaluated using a polygenic risk score (PRS) derived from a metagenome-wide association study, and the participants were categorized into low, intermediate, and high genetic risk groups based on their PRS for gout.
    • A favorable lifestyle was defined as having ≥ 3 healthy lifestyle factors, and 0-1 metabolic syndrome factor defined the ideal metabolic health status.
    • The incident CVD risk was evaluated according to genetic risk, lifestyle habits, and metabolic syndrome.

    TAKEAWAY:

    • Individuals in the high genetic risk group had a higher risk for CVD than those in the low genetic risk group in both the UK Biobank (adjusted hazard ratio [aHR], 1.10; P < .001) and KoGES (aHR, 1.31; P = .024) cohorts.
    • In the UK Biobank cohort, individuals with a high genetic risk for gout and unfavorable lifestyle choices had a 1.99 times higher risk for incident CVD than those with low genetic risk (aHR, 1.99; P < .001); similar outcomes were observed in the KoGES cohort.
    • Similarly, individuals with a high genetic risk for gout and poor metabolic health in the UK Biobank cohort had a 2.16 times higher risk for CVD than those with low genetic risk (aHR, 2.16; P < .001 for both); outcomes were no different in the KoGES cohort.
    • Improving metabolic health and adhering to a healthy lifestyle reduced the risk for CVD by 62% in individuals with high genetic risk and by 46% in those with low genetic risk (P < .001 for both).

    IN PRACTICE:

    “PRS for gout can be used for preventing not only gout but also CVD. It is possible to identify individuals with high genetic risk for gout and strongly recommend modifying lifestyle habits. Weight reduction, smoking cessation, regular exercise, and eating healthy food are effective strategies to prevent gout and CVD,” the authors wrote.

    SOURCE:

    This study was led by Ki Won Moon, MD, PhD, Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon, Republic of Korea, and Sang‑Hyuk Jung, PhD, University of Pennsylvania, Philadelphia, and was published online on October 8, 2024, in RMD Open.

    LIMITATIONS: 

    The definitions of lifestyle and metabolic syndrome were different in each cohort, which may have affected the findings. Data on lifestyle behaviors and metabolic health statuses were collected at enrollment, but these variables may have changed during the follow-up period, which potentially introduced bias into the results. This study was not able to establish causality between genetic predisposition to gout and the incident risk for CVD.

    DISCLOSURES:

    This study was supported by the National Institute of General Medical Sciences and the National Research Foundation of Korea. The authors declared no competing interests.

    This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.

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  • Dosa For Healthy Hair? This Dosa-Chutney Combo Will Nourish Your Hair From Within

    Dosa For Healthy Hair? This Dosa-Chutney Combo Will Nourish Your Hair From Within

    Our diet plays a key role in determining the health of our hair. If you are experiencing premature greying of hair, excessive hair fall due to weakening of hair roots or a receding hairline, then there is a big chance that your diet lacks biotin, magnesium, copper and zinc. Consuming foods rich in these essential nutrients can improve your hair health. In a recent Instagram video, nutritionist Rachna Mohan shared a simple and delicious Indian recipe for boosting hair health. This is a yummy ragi dosa paired with a chana-coconut chutney.

    The four main ingredients used in this recipe that are excellent for hair health are ragi (used in the dosa) and chickpeas, yogurt and coconut (used in the chutney).

    Here Is How These 4 Foods Boost Hair Health:

    1. Ragi

    Packed with essential nutrients like iron, calcium, and amino acids, ragi helps improve blood circulation to the scalp, promoting hair growth and reducing hair fall.

    2. Chickpeas

    High in protein and zinc, chickpeas nourish hair follicles and support stronger, healthier hair.
    Also Read:If You Are In Your Mid 20s, Start Drinking This Anti-Ageing Collagen Booster

    3. Yogurt

    Full of probiotics and protein, yoghurt promotes scalp health, reducing dandruff and inflammation that can cause hair fall.

    4. Coconut

    Rich in healthy fats and vitamins, coconut strengthens hair strands, preventing breakage and providing moisture.

    Desi ghee used for cooking this recipe is healthy for heart, brain and joints, the nutritionist adds in the video. Together, these ingredients provide the necessary nutrients to combat hair fall by nourishing the scalp, improving hair strength, and promoting healthy growth. Want to learn how to make this recipe? Read on!

    Recipe: Ragi Dosa With Chana-Coconut Chutney For Healthy Hair

    Begin by preparing the ragi dosa batter (click here for a detailed recipe) and spread it on a greased pan like mini uttapams. Add a little desi ghee and some delicious podi powder. Podi powder adds a delicious kick to this recipe. Now add finely chopped onions, tomatoes, bell peppers and grated carrots. Add a little grated cheese and press the toppings on the mini dosas. Let it cook well from both sides. Your ragi dosa with veggies is ready.
    Also Read: 5 Banana Peel Face Packs That Will Make Your Skin Glow Like Never Before

    For Chutney:

    Take a blender and add roasted chana, green chillies, ginger, coconut pieces and hung yoghurt. Blend it all well to form the chutney. Prepare a tadka with mustard seeds and curry leaves. Add the tadka to the chutney and mix well. The nutritious chutney is ready. Pair it with the ragi dosas and enjoy!

    Incorporate these healthy ingredients and recipe into your diet for healthy hair. For nutrient-rich foods for the skin, click here.



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  • Swiggy Calls Jalebi And Fafda “The Best Breakfast Combo”, Internet Reacts

    Swiggy Calls Jalebi And Fafda “The Best Breakfast Combo”, Internet Reacts

    Is the ‘jalebi and fafda’ combination the best breakfast combo? That is the cause of the latest debate on social media. It all started after food delivery platform Swiggy shared a post on X (formerly Twitter) saying that jalebi and fafda together are “the best breakfast combo”.  The picture features a plate of crispy and juicy jalebis, served with crunchy, fried fafdas. For the unversed, fafdas are a staple Gujarati snack prepared with gram flour, carom seeds and black pepper. The breakfast combo also includes a few green chillies for that spicy kick. “This is the best breakfast combo. You can’t change my mind (chef’s kiss emoji),” read the caption.

    The post sparked a debate among foodies. Agreeing with Swiggy’s breakfast idea, a person commented, “Breakfast mein jalebi fafda khane ki urge hai (I have the urge to eat jalebi fafda for breakfast).”

    Another suggested, “Bas ek cutting chai bhi add ho jaye, toh breakfast ka maza double ho jaye (Just add one cup of cutting tea and the breakfast fun will be doubled.)”

    A user called jalebi and fafda the “the ultimate duo”

    Also Read:6 Desi Food Combos That Are So Perfect They Are Probably Made In Heaven

    “Nice one! For targeting gujju audience,” read a remark. 

    One person had a different take on the matter. They wrote, “Basically Sugar with oil in breakfast. This is not healthy.”

    “Hard disagree” was a common reply. 

    Also Read:Former Swiggy Delivery Agent Turns Model, Internet Applauds

    A foodie shared a picture of poha, scrambled eggs, and cornflakes served with cucumber slices and yogurt in the comments section, underlining their kind of best breakfast. “I might not completely agree with that.”

    Previously, the internet went into a frenzy after Swiggy recommended having poha with tomato ketchup. A photo shared by Swiggy on X displayed a plate of poha seasoned with bhujia, curry leaves and nuts. A substantial amount of tomato sauce was drizzled on top, causing an outrage amongst foodies on X. Along with the post, Swiggy wrote, “The only right way to enjoy Poha.”

    What is your favourite breakfast combo? Tell us in the comments below. 



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